Hi Nick. Ford Perfect had a great post on this, which I will quote:
Ford sez:
"As for muscle hypertrophy (growth) there are two types of hypertrophy: myofabrillar and sarcoplasmic.
Myofabrillar hypertrophy is a growth in the muscles contractile proteins/fibers themselves. The muscle actually gets denser.
Sarcoplasmic hypertrophy is the growth in the amount of muscle sarcoplasm which is a jelly-like filler in between the contactile proteins from which the fibers extract their energy. Sarcoplasmic hypertrophy is generally what is responsible for most muscle “growth” (ie getting “jacked”)
FYI, there is a term called hyperplasia which refers to an increase in number of muscle fibers but it has been largely disproven.
Since you were asking about “growth”, I’ll concentrate on sarcoplasmic hypertrophy. Any hypertrophy is a result of the symbiotic relationship of intensity (as in % of your 1-rep max), rest time, and volume (amount of sets and reps). Since sarcoplasmic hypertrophy is a growth in the energy system in the muscle, it would make sense to target the energy system for the most growth.
This will lead to relatively low intensity, short rest, and moderate-high volume. The most obvious display of this is in the typical bodybuilder workout of 3 sets of 12 reps. 3 sets total is moderate volume, but if you condense rest periods to under a minute you will obviously be taxing the muscle’s energy systems. Doing 12 reps per set will also cause you to use low intensity since not many people can lift a high % of their one rep max 12 times!
Obviously you can play around with this relationship of intensity, rest, and volume. If you raise the intensity, then you must raise the volume. I only say this because as intesnity goes higher, the amount of reps you can do goes lower. Say if you are only doing 4 reps of an exercise. That means that will now have to do 9 sets instead of 3 to get those same 36 reps.
This is why it seems like there are so many approaches to reach the same goal. On the surface, they look radically different, but underneath it all are the same basic principles of the Energetic Theory of Muscle Hypertrophy: Intensity Volume Rest"
Fa-Jing sezs: Both kinds of hypertrophy lead to increases in strength, but only sarcoplasmic hypertrophy leads to much increase in muscle size. An olympic weightlifter in one of the lower weight classes would concentrate on myofabrillar hypertrophy. A bodybuilder OTOH would concentrate on sarcoplasmic hypertrophy. A strong man competitor, with no/little concern about his weight, probably concentrates on both.